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Peptide Synthesis (PSRG)

 
Participate in the 2001 Peptide Synthesis Research Group Study

The goals of the Peptide Synthesis Research Group is to assist members and their facilities in
  1. quality control
  2. problem solving
  3. introduction of new technologies.

Current Membership
Dr. Nicholas P. Ambulos (Ad hoc) - Univ of Maryland Sch of Med 
Preston Hensley (Ad hoc) (EB Liaison) - Lotus Translational Medicine 

Studies
1)Participate in the 2001 Peptides Synthesis Study
    - View Materials and Methods Form (2K)

Publications
1)Bonewald LF, Bibbs L, Kates SA, Khatri A, Medzihradszky KF, McMurray JS, Weintraub ST. Study on the synthesis and characterization of peptides containing phosphorylated tyrosine. J. Peptide Res. 53, 161-169, 1999.
2)Bonewald LF, Bibbs L, Kates SA, Khatri A, Medzihradszky KF, McMurray JS, Weintraub ST. 1997 ABRF Peptide synthesis research committee study on a peptide containing a phosphorylated tyrosine. In: Peptides: Frontiers of Peptide Science. Tam, J.P. and Kaumaya, P.T.P. (eds.). Kluver Academic Publishers, pp 705-706, 1999.
3)Bonewald LF, Angeletti RH: A guide to Peptide Synthesis and Peptide Facilities for Biomolecular Research In: Encyclopedia of Bioprocess Technology, MC Flickinger and SW Drew, (eds.) John Wiley & Sons, New York. (In press)
4)Angeletti RH, Bibbs L, Bonewald, LF, Fields GB, Kelly JW, McMurray JS, Moore WT, Weintraub ST. A multicenter study of racemization during standard solid-phase peptide synthesis. In; Peptides 1996, R Ramage and R Epton, (eds.) pp207-208, 1998.
5)Angeletti RH, Bonewald LF, Fields GB. Six Year Study of Peptide Synthesis. In: Methods in Enzymology Vol .289 pp 607-717, 1997.
6)Angeletti, R.H., Bibbs L., Bonewald, L.F., Fields, G.B., Kelly, J.W., McMurray, J.S., Moore, W.T. and Weintraub, S.T. 1997. Analysis of racemization during "standard" solid phase peptide synthesis: A multicenter study. In Techniques in Protein Chemistry VIII.(D.R. Marshak, ed.) pp. 875-890. Academic Press, Inc., San Diego.
7)Angeletti, R.H., Bibbs, L., Bonewald, L.F., Fields, G.B., McMurray, J.S., Moore, W.T. and Stults, J.T. 1996. Formation of a disulfide bond in a octreotide-like peptide: A multicenter study. In Techniques in Protein Chemistry VII. (D.R. Marshak, ed.) pp. 261-274. Academic Press, San Diego.
8)Fields, G.B., Bibbs, L., Bonewald, L.F., McMurray, J.S., Moore, W.T., Smith, A.J., Stults, J.T., Williams, L.C., and Angeletti, R.H. (1996) "Multi-center study of post-assembly problems in solid phase peptide synthesis." In: Peptides: Chemistry, Structure and Biology (P.T.P. Kaumaya and R.S. Hodges, eds.), Mayflower Scientific Ltd, pp. 52-54.
9)Fields, G.B., Angeletti, R.H., Bonewald, L.F., Moore, W.T., Smith, A.J., Stults, J.T. and Williams, L.D. 1995. Correlation of cleavage techniques with side-reactions following solid-phase peptide synthesis. In Techniques in Protein Chemistry VI. (J.W. Crabb, ed.) pp. 539-546. Academic Press, San Diego.
10)Fields, G.B., Angeletti, R.H., Carr, S.A., Smith, A.J., Stults, J.T., Williams, L.C. and Young, J.D. 1994. Variable success of peptide-resin cleavage and deprotection following solid-phase synthesis. In Techniques in Protein Chemistry V. (J.W. Crabb ed.) pp. 501-507. Academic Press, San Diego.
11)Fields, G.B., Carr, S.A., Marshak, D.R., Smith, A.J., Stults, J.T., Williams, L.C., Williams, K.R. and Young, J.D. 1993.Evaluation of a peptide synthesis as practiced in 53 different laboratories. In Techniques in Protein Chemistry IV. (R. Hogue-Angeletti ed.) pp. 229-237. Academic Press, San Diego.
12)Smith, A.J., Young, J.D., Carr, S.A., Marshak, D.R., Williams, L.C. and Williams, K.R. 1992. State-of-the-art peptide synthesis: Comparative characterization of a 16-mer synthesized in 31 different laboratories. In Techniques in Protein Chemistry III. (R. Hogue Angeletti, ed.) pp. 219-229. Academic Press, San Diego.
13)Bibbs, L., N.P. Ambulos, Jr., S.A. Kates, A. Khatri, K.F. Medzihradszky, G. Osapay and S.T. Weintraub. 2000. Strategies for the synthesis of labeled peptides. J. Biomol. Techn. Vol 11:155-165.
14)Medzihradszky, K., N.P. Ambulos, Jr., A. Khatri, G. Osapay, H.A. Remmer, A. Somogyi and S.A. Kates (2001) Mass spectrometry analysis for the determination of side reactions for cyclic peptides prepared from an Fmoc/tBu/Dmab protecting group strategy. Let. Peptide Sci. Vol8(1):1-12.
15)Ambulos, N.P., Jr., L. Bibbs, L.F. Bonewald, S. Kates, A. Khatri, K.F. Medzihradsky, and S.T. Weintraub (2000) Methods for analysis of synthetic peptides. In: F. Albericia and S.A. Kates, Eds., Solid phase Synthesis: A Practical Guide. Marcel Dekker, Pub., N.Y., pp751-789.
16)Bibbs, L., N.P. Ambulos, Jr., S.A. Kates, A. Khatri, K.F. Medzihradszky, G. Osapay, and S.T. Weintraub (2000) Strategies for the synthesis of labeled peptides. In. G. Barany and G. Fields, Eds, Peptides for the new millennium, proceedings of the 16th American Peptide Symposium.

Membership History
Member NameOrganizationDetails
Dr. Nicholas P. AmbulosUniv of Maryland Sch of Med Chair: 01/00 - 01/03
Member: 01/98 - 01/00
Ruth AngelettiAlbert Einstein Col of Med Chair: 01/95 - 01/96
Member: 01/93 - 12/94
Member: 01/96 - 01/98
Dr. Lynda F. BonewaldUniv. of Missouri at Kansas City Chair: 01/96 - 01/98
Ad hoc: 01/94 - 03/02
Steven CarrMillennium Pharmaceuticals, Inc. Member: 01/91 - 01/93
Dr. Gregg B. FieldsUniv. Texas Health Sci. Center Chair: 01/91 - 01/94
Ad hoc: 01/94 - 01/95
Dr. Mark O. LivelyWake Forest Univ. Sch. of Med. Ad hocEb Liaison: 03/02 - 01/03
William MooreUniv Pennsylvania Sch of Med Member: 01/93 - 01/96
Dr. Henriette A. RemmerUniversity of Michigan Member: 01/99 - 03/01
Ad hoc: 03/02 - 01/03
Alan J Smithsomerset consulting Member: 01/91 - 01/94
John StultsGenentech Inc Member: 01/92 - 01/95
Dr. Sandra Vigil-CruzUniversity of Kansas Member: 01/01 - 01/03
Dr. Susan T. WeintraubUniv. of Texas Health Science Center at San Antonio Member: 01/95 - 01/00
Ken R. WilliamsYale Univ, Keck Lab Member: 01/91 - 01/93
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