| 1) |
sPRG BIC2007 Study
In 2005, the ABRF Proteomics Standards Research Group (sPRG) created a proteomics standard composed of 49
highly purified human proteins in an equimolar mixture. The sPRG conducted a blind study to assess the proteomics
community’s ability to determine the identities of the constituent proteins using their proteomics platforms of choice.
The results of this study were presented at ABRF 2006 in Long Beach, CA. The study revealed the value of multiple
independent analyses of this proteomics standard, and contributors were asked to voluntarily contribute their datasets
for future public distribution. Approximately 30 datasets were submitted representing a wide variety of proteomics
strategies and mass spectrometry platforms.
The sPRG Bioinformatics Committee (BIC) has analyzed these datasets in detail using a wide variety of informatics
tools. Generating a definitive list of protein constituents was our initial goal. In addition, we present metrics for
quality assessment from these data, and we demonstrate statistical approaches for determining false positive rates. We
also explore the complex issues resulting from protein sequence homology. The ABRF sPRG2006 Proteomics
Standard constitutes a valuable dataset for the evaluation of proteome informatics tools.
- View Press Release - March 2007
- View Poster - BIC2007
(1,209K)
- View Presentation Slides - BIC2007
(4,020K)
- Download sPRG BIC DB (zipped archive)
(5,547K)
- Download sPRG BIC Final Protein List
(37K)
- Download Metadata on sPRG2007 datasets.xls
(18K)
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| 2) |
iPRG2008 Study Materials
- View Study Announcement
(23K)
- Study database with concatenated decoys (fixed)
(30,485K)
- Study database (fixed)
- MGF format peak list set
(5,132K)
- Raw data - PART1
(33,253K)
- Raw data - PART2
(30,218K)
- Raw data - PART3
(25,498K)
- Raw data - PART4
(28,933K)
- Raw data - PART5
(26,564K)
- mzData format peak lists
(7,585K)
- mzXML format peak lists
(5,332K)
- DTA format peaklists
(16,203K)
- Required Excel results template
(23K)
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| 3) |
iPRG2008 Study - Initial Results Presentation at ABRF2008
- ABRF2008 Poster
(2,055K)
- ABRF2008 Slides
(728K)
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